• Dendritic damage and loss of synaptic connections correlate

  2022-03-09

  

  Dendritic damage and loss of synaptic connections correlate with cognitive decline in HAND patients. Synapse loss induced by HIV proteins occurs early and via a different signaling pathway from that leading to neuronal death (Kim et al., 2008), suggesting that synapse loss might be a mechanism to re

• br Methods br Acknowledgements The authors thank the ZLS

  2022-03-09

  

  Methods Acknowledgements The authors thank the ZLS group members, particularly Li Li and Elijah Roberts, for many helpful discussions. They also wish to thank Nathan Baker for APBS assistance, Jan Jensen for help with PROPKA 2.0, Susan Martinis for experimental interpretations, and John Stone

• It is widely acknowledged that a significant gap exists betw

  2022-03-09

  

  It is widely acknowledged that a significant gap exists between the increasingly detailed knowledge of subcellular mechanisms and the ability to control large-scale anatomy. Radical advances in regenerative medicine require approaches aimed at taming the fundamental complexity of cellular regulation

• br Discussion The model of a NVU described by

  2022-03-09

  

  Discussion The model of a NVU described by Mathias et al. (2018) has been implemented on the macro scale (see Kenny et al. (2018b)) via a 2D cerebral tissue slice coupled to a vascular tree. In particular, further communication within the tissue slice has been implemented via extracellular ion el

• br Summary The presented results of

  2022-03-09

  

  Summary The presented results of the analysis of the unfolding of G-quadruplex and i-motif, which may appear within the telomeric DNA region, led to several important conclusions. Namely, determination of the work necessary to unfold of these structures, in biased molecular dynamics involving ste

• Homeobox genes can promote oncogenesis through multiple mech

  2022-03-09

  

  Homeobox genes can promote oncogenesis through multiple mechanisms, including gene translocation, loss of heterozygosity, gene amplification, DNA methylation, Doxorubicin remodeling, etc. For instance, translocation-mediated fusion of HOXA9 or HOXA13 on chromosome 7p15 with the nucleoporin gene NUP

• Activation of FXR or TGR inhibits inflammatory

  2022-03-09

  

  Activation of FXR or TGR5 inhibits inflammatory response via repressing NF-κB activity [1]. FXR is not expressed or expressed at a very low level in macrophages [45] (data not shown), but highly expressed in hepatocytes. In contrast, TGR5 is expressed in macrophages but not in hepatocytes. Our data

• Compound C A common feature of ferroptosis is

  2022-03-09

  

  A common feature of ferroptosis is the iron-dependent accumulation of lipid-ROS and the subsequent depletion of polyunsaturated fatty Compound C phospholipids (PUFA-PLs) [118]. The PUFA chains of membrane lipids are more susceptible to both enzymatic and non-enzymatic oxidation, which results in PU

• Sumoylation of transcription factors has been generally link

  2022-03-09

  

  Sumoylation of transcription factors has been generally linked to transcriptional repression and, in a few cases, to transcriptional activation [60] Accumulating evidence implies that corepressor complex subunits, including CoREST, CtBP, Daxx, NCoR1, SMRT and histone deacetylase complexes (HDACs), p

• Introduction Thrombotic disorders including ischemic heart d

  2022-03-09

  

  Introduction Thrombotic disorders including ischemic heart disease, deep venous thrombosis, and ischemic stroke represent one of the most common causes of death in the world [1]. All these conditions relate to states accompanied by a shift of hemostasis balance into a coagulation side because of va

• FXa is a vitamin K dependent

  2022-03-09

  

  FXa is a vitamin K-dependent serine protease consisting of two chains linked by a disulfide bridge. The heavy chain contains 303 FK-228 and the light chain has 139 amino acids. The catalytic triad comprised of Ser195, His57, and Asp102  exhibits the trypsin-like β-barrel structure [12]. The active

• The above inferences concluded that

  2022-03-09

  

  The above inferences concluded that histidine is enhancing the overall stability and rigidity of the protein which further might be restraining the protein during the transition from inactive to active state and vice-versa present in the SANT domain. Since the SANT domain binds with histone via elec

• CBR-5884 receptor br Experimental br Acknowledgments br

  2022-03-09

  

  Experimental Acknowledgments Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS), and without treatment results in a debilitating disease that cripples the immune system of the patient, increasing susceptibility to opportunistic diseases

• The multiple regression analysis showed that testing during

  2022-03-08

  

  The multiple regression analysis showed that testing during summer and autumn was associated with higher histamine reactivity, which could be associated with the presence of pollen in the air. Gamboa et al. reported that more histamine was released during spring and autumn than during the other two

• Allergic rhinitis characterized by inflammation

  2022-03-08

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to PKI 14-22 amide, myristoylated in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in tr

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