• Analyzed by qRT PCR Fig the variation of the

  2023-09-11

  

  Analyzed by qRT-PCR (Fig. 8), the variation of the expressions of DtACLA and DtACLB was fairly consistent in response to nitrogen deficiency, suggesting that DtACLA and DtACLB may be coordinate to function in the catalysis. It was reported that in Arabidopsis, the coordinated ACLA and ACLB mRNA accu

• The phylogenetic relationship demonstrates that both

  2023-09-11

  

  The phylogenetic relationship demonstrates that both bovine and porcine 12/15-LO is more related to the human enzyme than the rabbit enzyme, despite the fact that the rabbit reticulocyte enzyme is a 15-lipoxygenase. The rabbit is one single species that expresses a 12/15 LO with 15-LO activity while

• Another contributor for the G M arrest

  2023-09-11

  

  Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks 516 3 australia G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al., 2

• br Materials and methods br Results

  2023-09-11

  

  Materials and methods Results and discussion During recent years, recombinant ASK1 has been obtained by expensive baculovirus-insect cell Autophagy Compound Library systems [20], [27]. In the present study, we constructed recombinant ASK1 and expressed in active form at high level in E. coli.

• br Materials and methods br Results br Discussion The curren

  2023-09-11

  

  Materials and methods Results Discussion The current treatment modalities for colorectal cancer are hampered by various issues such as high acquired resistance, long-term complication with potential of cancer recurrence, severe side-effects and poor therapeutic index [50], [51], [52]. Compl

• Apelin is a bioactive peptide and endogenous ligand

  2023-09-11

  

  Apelin is a bioactive peptide and endogenous ligand for the APJ receptor (APLNR), a member of the G protein coupled receptor family that shares a similar sequence as the angiotensin type-1 receptor (AT1) [5]. Early studies demonstrated that the apelin/APLNR receptor axis plays a significant role in

• Boc-Phe-Osu Infections inflammation and corneal transplant c

  2023-09-09

  

  Infections, inflammation, and corneal transplant can all cause corneal neovascularization via upregulation of inflammatory cytokines, which attract myeloid Boc-Phe-Osu into the cornea. These myeloid cells establish a cycle of cytokine secretion and further myeloid cell recruitment in the cornea. Th

• br Antiangiogenic therapy in non small cell lung

  2023-09-09

  

  Antiangiogenic therapy in non-small cell lung cancer (NSCLC) Antiangiogenic targeted therapy is an area of active research in which numerous agents have been studied and have been shown to be effective for many tumor types including NSCLC. Angiogenesis is frequently upregulated in malignant solid

• Fmoc-Ala-OMe br Prostate cancer and resistance to AR targeti

  2023-09-09

  

  Prostate cancer and resistance to AR targeting treatment The AR plays a pivotal role in the development, differentiation, homeostasis and secretory function of the normal prostate (Wilson, 2011). The AR is also a key player in many phases of prostate carcinogenesis (Huggins et al., 1941, Scher an

• br AR expression in breast tissue Although

  2023-09-09

  

  AR expression in breast tissue Although androgenic signalling is chiefly associated with the development and maintenance of primary and secondary male characteristics, especially during puberty when the testes are by far the major source of testosterone, the AR also plays important functions in f

• br Acknowledgements This work was supported by a grant from

  2023-09-09

  

  Acknowledgements This work was supported by a grant from the National Science Foundation (IOS- 1353366), the Hatch Program of the National Institute of Food and Agriculture (VA-135908) and the Virginia Agricultural Experiment Station, to G.P. Introduction With steadily rising number of affect

• br Concluding Remarks and Future Perspectives While postmort

  2023-09-09

  

  Concluding Remarks and Future Perspectives While postmortem human leukotriene receptor antagonist material is relatively sparse and has inherent limitations as discussed above, additional investigations could benefit from analysis of in vitro cellular models to corroborate findings in patient ma

• br Discussion To our knowledge this is the

  2023-09-09

  

  Discussion To our knowledge, this is the first case report that demonstrates the presence of a novel T1151K ALK mutation in a patient with disease progression after crizotinib and then ceritinib. As early as 2011, Zhang et al. identified T1151K among other resistance mutations to crizotinib in Ba

• Targeted disruption of the Akt

  2023-09-09

  

  Targeted disruption of the Akt1 gene in mice induces a growth retardation phenotype [4,19]. Akt2 KO mice reveal mild growth retardation and insulin resistance [4,20,21]. Akt1/2 double KO (DKO) mice display severe growth deficiency and die shortly after birth. These mice exhibit impaired bone and ski

• terbinafine hydrochloride mg br Materials and Methods br Res

  2023-09-09

  

  Materials and Methods Results Discussion Voluminous literature is available describing the regulation of terbinafine hydrochloride mg homeostasis by central and peripheral mechanisms in poultry [35,36]. However, the neuroendocrine mechanism(s) of photoperiod induced hypothalamic regulation

15943 records 277/1063 page Previous Next First page 上5页 276277278279280 下5页 Last page