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Desfuroylceftiofur In contrast to SQLE HMGCR could be effici
2019-09-03
In contrast to SQLE, HMGCR could be efficiently degraded in Desfuroylceftiofur lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our
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Due to the high attractiveness of E and E
2019-09-03
Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence (Dudgeon et al., 2010, Krist et al., 2016, Zhang et al., 2004), ML 221 pathway (Davydov et al., 2004, Huang et al., 2005, Kenten et al., 2005
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E is a classical initiator protein and as such
2019-09-03
E1 is a classical initiator protein and, as such, plays several roles in the initiation and catalysis of viral DNA synthesis. E1 must first recognize a specific segment of the viral BET bromodomain inhibitor known as the “origin of DNA replication”, or “ori” for short. For most PV types examined to
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sglt-2 br Methods and materials br Cyclooxygenase COX is
2019-09-02
Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic sglt-2 to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that is expressed in many
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Baicalein trihydroxyflavone was first isolated from
2019-09-02
Baicalein (5,6,7- trihydroxyflavone) was first isolated from the roots of Scutellaria baicalensis Georgi (Lamiaceae family), a medicinal plant with diverse therapeutic implications; antibacterial, antiviral, and anti-inflammatory properties. It has been found that baicalein benefits neuroinflammatio
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br Materials and methods br Results br Discussion
2019-09-02
Materials and methods Results Discussion Although some conditioning therapies have provided satisfactory clinical outcomes, mammalian species have little or no ability to replace injured cardiac tissue [34]. Therefore, therapeutic strategies based on the prevention, rather than treatment af
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Celiac disease occurs in the small intestine due to
2019-09-02
Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they
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The discoidin domain receptors DDR and DDR
2019-09-02
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by different types of collagen (Shrivastava et al., 1997, Vogel et al., 1997). Both receptors interact with a number of fibrillar collagens, and DDR1, but not DDR2, is also activated by the network-formin
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The overall shape of p
2019-09-02
The overall shape of p110α/iSH2 is dramatically different from DGKB or SK1, instead of forming a homodimer, p110α/iSH2 heterodimer has a triangular shape with iSH2 laying on the top and ABD, RBD, helical and kinase domain of p110α sitting in the bottom (Fig. 2B) (Gabelli et al., 2010; Huang et al.,
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Soybean Glycine max is an
2019-09-02
Soybean (Glycine max) is an important oilseed and can be a useful source of epoxy fatty acids (EFAs). This UFA contains an oxygen bridge across adjacent carbon atoms at single or multiple positions in the acyl chain, making them highly reactive and prone to cross-linking, and thus valuable industria
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br Introduction The allergic response is a complex process i
2019-09-02
Introduction The allergic response is a complex process involving the interaction of several mediators; among these, cysteinyl leukotrienes (CysLTs) represent one of the most important actors in the pathogenesis of airway allergic diseases such as allergic rhinitis and asthma [1]. Pharmacological
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Yang et al investigatedPsoralidin a coumestan
2019-09-02
Yang et al. investigatedPsoralidin 39, a coumestan derivative isolated from the seed of Psoralea corylifolia, regarding its effects on IR-induced pulmonary inflammation. Psoralidin 39 inhibited the IR-induced COX- 2 expression and PGE(2) production through regulation of PI3K/Akt and NF-κB pathway. A
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br Methodology The following subsections describe the steps
2019-09-02
Methodology The following subsections describe the steps of the Systematic Literature Review (SLR) process we followed [9]. Results In our review of the literature, we used the definitions provided by the IEEE Standard Computer Dictionary [15] to categorize the claims about the effectiveness
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Activating GSK signaling to inhibit PK signaling during isch
2019-09-02
Activating GSK3β signaling to inhibit PK signaling during ischemia/reperfusion (I/R) is protective of WM ischemic injury. Glycogen synthase kinase (GSK3), which was the first substrate identified for AKT [44], is inhibited by AKT phosphorylation at positions S9 and S21 [45]. When GSK3β is active, it
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Proteolysis by CPs is crucially
2019-08-30
Proteolysis by CPs is crucially important for cereal seed development and germination. However, these enzymes must be tightly controlled. Pre-harvest sprouting is a phenomenon in which the control of CPs is disrupted. This disruption manifests in the premature synthesis and activation of CPs, leadin
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