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Alternatively receptors may be customized to fulfill
2020-07-28
Alternatively, receptors may be customized to fulfill novel tasks, as has been demonstrated for the modular extracellular sensor architecture (MESA) receptors that enable ESI-09 to sense vascular endothelial growth factor (VEGF) and, in response, secrete IL-2 [94]. MESA receptors are composed of a
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br Acknowledgements br Introduction Nonmelanoma skin cancer
2020-07-28
Acknowledgements Introduction Nonmelanoma skin cancer (NMSC) is the most common cancer in fair skinned populations. Exposure to UV radiation, along with fair skin, immune status and HPV infection, are the greatest risk factors (Akgul et al., 2006a, Feltkamp et al., 2008). A link between HPV in
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The relationship between the hazard
2020-07-28
The relationship between the hazard function and the survivor function (see more details in Allison\'s textbook [1]) is described as or as Hence, we can estimate the survival probability from the hazard function. In survival analysis, the hazard function can be represented by any probability distrib
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acridine orange br Related work The use
2020-07-28
Related work The use of cloud-based computing, as previously described in [33], offers a number of advantages for both users and organizations who want to make better use of the resources they manage. Among the benefits identified, that study refers to the use of SaaS, and specifically of MaaS a
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Working under the hypothesis that differences in COMT
2020-07-28
Working under the hypothesis that differences in COMT are associated with aberrant ethanol seeking and intake, the current project sought to investigate the influence of alterations in COMT activity and expression on alcohol seeking and drinking. While sex-linked differences in COMT protein expressi
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br Conflicts of interest br Acknowledgments This study
2020-07-28
Conflicts of interest Acknowledgments This study was supported by the Beijing Natural Science Foundation (No.7192015), the Great Wall scholars program of Beijing Municipal Education Commission (No.CIT&TCD20180308) and Beijing Municipal Commission of Education Research Projects (Grant No. KM201
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The decrease of HVPG on day seems to be
2020-07-28
The decrease of HVPG on day 6 seems to be less marked than on day 0. Pharmacokinetic data showed that already in the 25mg/day group, a trough level of udenafil (about 1/5 of peak level) could be detected on day 6 prior to the next drug administration. Therefore, it could be speculated that in the 75
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Cholesterol lowering is consistent with previously
2020-07-27
Cholesterol lowering is consistent with previously reported observations (Bijland et al., 2011, Curran et al., 2008, Seacat et al., 2002, Seacat et al., 2003) and likely is modulated, in part, by enhanced PPAR-mediated fatty sirtuin 1 oxidation. The attenuation of effects in recovery followed dimi
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The reduced DNA stability at RH confirms previous results
2020-07-27
The reduced DNA stability at 100% RH confirms previous results for incubates at these conditions, although in the present study amplifiable DNA still survived for months. The crucial point appears to be the onset of microbial growth, which happened at room temperature and at 35 °C. In the biological
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br The role of chemokine and AD Chemokines are small
2020-07-27
The role of chemokine and AD Chemokines are small cytokine proteins that are involved in various immunological and physiological functions. These proteins can be involved in cell migration and localization during homeostasis and inflammation, and as such, they were named chemokines [80]. Chemokin
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This provides the rationale that covalent or non covalent
2020-07-27
This provides the rationale that covalent or non-covalent inhibitors of rhodesain may be advanced into the drug development pipeline against African sleeping sickness. To discover rhodesain inhibitors, we employed the irreversible tethering method to discover covalent inhibitors of cysteine protease
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In conclusion CysLT receptors were
2020-07-27
In conclusion, CysLT2 receptors were constitutively expressed in bronchial smooth muscle cells of BALB/c mice. Multiple antigen challenges induced infiltration of CysLT2 receptor-expressing leukocytes (eosinophils and macrophage/dendritic cells) into the lung in sensitized BALB/c mice. CysLT2 recept
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Because flavonoids are widely considered to contribute to
2020-07-27
Because flavonoids are widely considered to contribute to health benefits in humans, including anti-inflammatory, antibacterial, antiviral, anticancer, antiplatelet properties, and free radical scavenging capacity (Xiao et al., 2011), efforts have frequently been made to increase their bioavailabili
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In reviewing the literature it is apparent that three
2020-07-27
In reviewing the literature, it is apparent that three major methodological approaches are used to evaluate the behavioral effects induced by targeted BOP reagent alterations. These methods include knockout procedures, antisense oligonucleotide strategies, and administration of specific CRF recepto
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One of the genes whose expression was down regulated
2020-07-27
One of the genes whose expression was down regulated was bgt-2 (NCU09175), encoding a β-1,3-endoglucanase. Deletion of this gene was shown to result in changes in CTX0294885 mg architecture suggesting that it is involved in remodeling of the cell wall (Martínez-Núñez and Riquelme, 2015). Among the o
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