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The purposes of this study
2020-07-30
The purposes of this study are to investigate the molecular function of DDR2, especially in cellular proliferation in prechondrocytes, and to examine the relationship between the proliferation and differentiation of prechondrocytes through both in vitro and in vivo analysis. Materials and methods
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In mammals DEX can initiate
2020-07-30
In mammals, DEX can initiate hexokinase inhibitor of CYP2E1 (Sampol et al., 1997). The CYP2E1-like protein activity has also been identified in fish (Kaplan et al., 1999, Wall and Crivello, 1999, Zamaratskaia and Zlabek, 2011). To date, there are no reports on the in vivo effect of DEX on PNPH acti
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ryanodine br Role of Cdk in plaque formation In AD
2020-07-30
Role of Cdk5 in plaque formation In AD pathogenesis, the key component of amyloid plaques is the accumulation of amyloid-β peptide (Barucker et al., 2015, Mawuenyega et al., 2010). Aβ is formed due to the sequential cleaving of integral membrane glycoprotein APP by β-secretase (BACE1) succeeded b
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With potent activity established against primary human
2020-07-30
With potent activity established against primary human inflammatory cell types, we next characterized 18 in CRTh2-dependent rodent mechanistic and allergic disease models. Intra-tracheal installation of DK-PGD2 in IL-5 primed rats leads to a time and dose-dependent recruitment of leukocytes (particu
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In our previous study intracerebroventricular administered u
2020-07-30
In our previous study, intracerebroventricular-administered urocortin-2 enhanced a conditioned freezing fear response and significantly decreased rat exploratory activity in the open field test [9]. Exogenous urocortin-2 enhanced the conditioned fear-induced expression of c-Fos in the central amygda
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A more detailed description of higher order thinking is
2020-07-30
A more detailed description of higher-order thinking is offered by King, Goodson, and Rohani (1998): “Higher order thinking skills include critical, logical, reflective, metacognitive, and creative thinking. They are activated when individuals encounter unfamiliar problems, uncertainties, questions
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br Overall architecture of the proposed recommender system
2020-07-30
Overall architecture of the proposed recommender system In this section we describe the overall architecture of the proposed recommender system. Although dozens of recommender systems in software engineering have been built, no reference architecture has emerged to-date (Robillard et al., 2014).
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R 59-022 sale In addition to playing important roles in the
2020-07-29
In addition to playing important roles in the immune system, EBI2 is also expressed in the R 59-022 sale of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkowska et al., 2016a). Mo
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br Negative regulation of DUBs While all DUBs
2020-07-29
Negative regulation of DUBs While all DUBs discussed so far are activated by intramolecular domains or external proteins, in a limited number of rare cases DUBs are directly inhibited by other proteins. The first example of this type is UCH-L5 inhibition by INO80G. INO80G is a metazoan-specific s
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br Introduction Anaplastic large cell ALCL lymphomas
2020-07-29
Introduction Anaplastic large-cell (ALCL) lymphomas represent the 2% of the non-Hodgkin lymphomas. These types of lymphomas, as well as the Hodgkin/Reed-Sternberg (H-RS) lymphoma A 804598 [1] overexpress CD30, a member of the TNF receptor family [2]. CD30 has been implicated in cell survival and
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The biological importance of the
2020-07-29
The biological importance of the signaling pathway(s) elicited by CHK is not fully comprehended. Ras, identified here as a signal transducer acting downstream to CHK (Fig. 4C and D), is a potent oncogene and mutated forms are found in approximately 30% of all human cancers [41]. In contrast to its g
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Similar to what is observed in rectal cancer surgery
2020-07-29
Similar to what is observed in rectal cancer surgery, erectile dysfunction after radical prostatectomy is associated with intraoperative injury to the nerves. Recovery of erectile function after such injury requires a certain convalescence period. PDE-5 inhibitors have been used to improve erectile
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The availability of D selective ligands
2020-07-28
The availability of D3-selective ligands has enabled study of the distinct roles of D2 and D3 receptors both in vivo and in vitro. For example, behavioral pharmacology studies have indicated that the D3 receptor plays an important role in mediating the reinforcing effects of psychostimulants such as
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TG101209 Comet assay is a widely
2020-07-28
Comet assay is a widely accepted method for assessing DNA damage in individual cells. It can be used to measure single-strand or double-strand DNA breaks, alkali labile sites, DNA crosslinks, base/base-pair damages and apoptotic cells. This method was introduced by Ostling and Johanson [2] in 1984,
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br Experimental The compounds were synthesized at Department
2020-07-28
Experimental The compounds were synthesized at Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University, Cairo. Melting points (°C) were determined on Mettler FP80 melting point apparatus and are uncorrected. Microanalyses were perf
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