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The current study provides evidence for a previously
2021-01-04
The current study provides evidence for a previously unknown role for DHODH as a growth/survival factor in KRAS mutant tumors. While many aspects of the link between DHODH inhibition and survival of KRAS mutant cells remain to be established, de novo pyrimidine biosynthesis appears to be a crucial p
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br Conflict of interest br Acknowledgments Dr
2021-01-04
Conflict of interest Acknowledgments Dr. Hauger was supported by a BLR&D Merit Review grant from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development. Dr. Hauger also received support from the VA Center of Excellence for Stress and Mental Healt
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Two are the sigma receptors identified to date
2021-01-04
Two are the sigma receptors identified to date: the non-opioid receptor, σ1R, and σ2R, whose identity with the Progesterone Receptor Membrane Component 1 (PGRMC-1) protein is in doubt (Chu et al., 2015). Despite endogenous ligands have not been yet identified, drugs of abuse may interact with these
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br Results br Discussion Cell
2021-01-04
Results Discussion Cell responds to fluctuating environmental factors by activating a set of compensatory mechanisms including changes in the lipid profile. Compensatory reactions occurring in membranes in response to phosphate deprivation include replacement of phospholipids by phosphorus-fre
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Gap19 receptor Carnitine acetyltransferase CrAT transesterif
2021-01-04
Carnitine acetyltransferase (CrAT) transesterifies short-chain acyl-CoAs, and is located both in mitochondria and peroxisomes. In yeasts and mammals this protein is the product of a single gene [20,21] and the sorting to different organelles is evolutionary conserved, although the mechanism of diffe
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The UI compo http www apexbt com media
2021-01-04
The UI components used in our proposal are called COTSgets, from COTS (Commercial Off-The-Shelf) [28] and gadgets (understood as any software that can work alone or as a piece of the architecture). A COTS component is any coarse-grained component developed by third parties available for building mor
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During the first year of life
2021-01-04
During the first year of life, there was no interaction between cholesterol precursors and cholestanol, suggesting that cholesterol homeostasis was not yet developed. From the age of 1 year, cholesterol homeostasis could be considered intact. According to Fig. 1, cholesterol NVP-LCQ195 prevailed ch
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br Experimental br Acknowledgments The work was supported
2020-12-31
Experimental Acknowledgments The work was supported in part by the National Research and Development Plan (2017YFD0200506), the National Natural Science Foundation of China (21472062 and 31701820), 111 Project B17019, and excellent doctoral dissertation cultivation Grant from Central China Nor
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br A brief introduction to DUBs The reversal of ubiquitin
2020-12-31
A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating nisoldipine (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be classified int
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According to our results germination of transgene dgks lines
2020-12-31
According to our results, germination of transgene dgks lines didn’t differ under optimal conditions and 50 mM NaCl, while 100 mM NaCl slightly affected germination rates of dgk mutants. Exogenous application of EBL even diminished the effect of 100 mM NaCl on dgk mutants. The critical effect on ger
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Funding sources This study was funded by
2020-12-31
Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg
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br Molecular modeling simulation study
2020-12-31
Molecular modeling simulation study Molecular modeling study was performed through docking of the test compounds into the binding site of hDHFR enzyme using Discovery Studio 2.5 software. Computational docking is an algorithm designed to determine the suitable position and the orientation of the
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In recent years neuroimaging studies have
2020-12-31
In recent years, neuroimaging studies have increasingly demonstrated acute effects of THC on Cefepime Dihydrochloride Monohydrate function, the vast majority of them involving a cognitive challenge (Bossong et al., 2014b). For example, without affecting performance accuracy, THC caused reductions i
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wee1 inhibitor Next we evaluated the therapeutic potential o
2020-12-31
Next, we evaluated the therapeutic potential of compound () using the mouse model of collagen-induced arthritis (CIA model), which is the pathological model for RA. Consequently, oral once-daily dosing of 3 mg/kg reduced the overall progression of the clinical score, including inflammation and bone
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br The amygdala complex The amygdala complex is composed
2020-12-31
The amygdala complex The amygdala complex is composed of distinct nuclei and subdivisions including the lateral (LA), basolateral (BL), and basomedial (BM) amygdala; the medial (Imp), lateral paracapsular (lpc), and main intercalated cell cluster (IN); and the lateral and medialcentral amygdala (
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