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br COTSget based Architectures This section describes how
2021-06-22
COTSget-based Architectures This section describes how our COTSget-based architectures are defined. We use a design inspired by MDE to build a Domain-Specific Language (DSL) of the architecture, as can be seen in the metamodel of Fig. 3. This metamodel defines the abstract syntax of our DSL and i
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It is interesting that of the control groups female TG
2021-06-22
It is interesting that of the control groups, female TG controls only had significantly higher MB-COMT protein than non-TG male controls (Supplemental Table 9, P = 0.005), while these two groups have almost equal expression of S-COMT protein (8.54- vs. 8.34-fold) and their COMT enzyme activity is al
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There are some limitations to our study First the
2021-06-22
There are some limitations to our study. First, the small sample size, even if comparable or higher than most studies, did not offer the possibility to consider other variables, such as frequency of use or age of onset. Second, since most subjects did not report current use, we could not analyze sep
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Damage of PE HD due to both mechanisms is
2021-06-22
Damage of PE-HD due to both mechanisms is usually considered to emerge from a local stress concentration in the material, leading to the initiation of a crack, which subsequently propagates further through the material, and finally leads to macroscopic failure. In this process, crack growth occurs o
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Current therapeutic protocols in OS and ES consist of neoadj
2021-06-22
Current therapeutic protocols in OS and ES consist of neoadjuvant chemotherapy and local surgical resection, followed by adjuvant chemotherapy. These treatments lead to a 70% overall survival for localized disease but can decrease to 15% in case of metastasis. With CS being resistant to conventional
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br Epac in cardiovascular pathophysiology Epac orchestrates
2021-06-22
Epac in cardiovascular pathophysiology Epac orchestrates signaling actors that regulate fundamental cellular functions and general biological effects. However, some important gaps still remain in the knowledge of the physiopathological role of Epac in the heart. So far, Epac has been implicated i
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EP is the major receptor to
2021-06-22
EP4 is the major receptor to mediate PGE2-induced inflammatory pain. EP4 is upregulated by phosphocholine in DRG neurons [16]. Intrathecal injection of the EP4 agonist produced pain responses [25]. Either systemic or local injection of EP4 antagonists relieves inflammatory pain [3], [16], [26]. How
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The Penicillium strain used in this
2021-06-21
The Penicillium strain used in this work was isolated from Atlantic forest soil and previously screened as lipase producer (Tauk-Tornisielo et al., 2005). The immobilization was previously evaluated using hydrophobic supports, i.e. agarose based butyl-(But), phenyl-(Phe) and octyl-Sepharose (Oct), a
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Herbal products may alter the metabolism of
2021-06-21
Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 ARCA (CYP). These can bring about an alteration of the pharmacokinetics and pharmacological activity
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Although the amino acid sequences of
2021-06-21
Although the amino k145 sequences of CUL4A and CUL4B share 82% identity, the existing studies have shown that these two proteins do not have significant functional redundancy. Elevated expression of CUL4A has been observed in a variety of cancer cells, such as breast cancer, ovarian cancer, liver c
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In all available E E structures the RING type domain
2021-06-21
In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans
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br Materials and methods br Results br Discussion UPP
2021-06-21
Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important AM095 of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation system [2
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br Results and discussion br Conclusion A new
2021-06-21
Results and discussion Conclusion A new series of 2-mercapto-quinazolin-4-one analogues is designed and synthesized to possess electron withdrawing or donating functional groups (Cl or CH3O) at position 6- or 7-, 4-methoxyphenyl function at position 3. The 2-mercapto function is used to connec
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Significantly less is known about regulation of phytocystati
2021-06-21
Significantly less is known about regulation of phytocystatin gene expression. A genomic clone corresponding to the barley cystatin Icy gene has been characterized (Gaddour et al., 2001) and the function of its promoter region has been analysed by Martínez et al. (2005b). Bioinformatic analysis of t
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Introduction The term myeloproliferative disorders was
2021-06-21
Introduction The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myelopro
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