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br Soluble guanylyl cyclase nitric oxide
2021-09-09
Soluble guanylyl cyclase, nitric oxide and nitric oxide synthase The primary and best-studied endogenous activator of soluble guanylyl cyclase (sGC) is nitric oxide (NO), which was originally describe as endothelium-derived relaxing factor for its potent ability to relax blood vessels in response
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In order to better manage HBV infection and related
2021-09-09
In order to better manage HBV infection and related liver diseases, it is critical to develop new antiviral strategies to increase the rate of functional or complete cure of HBV infection (HBsAg loss and cccDNA elimination), achieving more than viral suppression (Zeisel et al., 2015). As a result, m
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Bioinformatic analysis revealed a putative coiled coil
2021-09-08
Bioinformatic analysis revealed a putative coiled-coil SLD within CT229 which we show to be essential for intracellular replication and recruitment of Rab GTPases to the inclusion. Mutation of a single amino apigenin mg residue in the SLD domain (CT229L120D) significantly reduced Rab binding and re
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br Materials and Methods br Results All of
2021-09-08
Materials and Methods Results All of the studied transporter genes were expressed at detectable levels in all the analyzed samples at mRNA level by means of applied rt-PCR method (CTlowest lactone was observed for ABCC4, ABCC1, ABCG2, SLC22A3, and SLC22A18 (less than 10% of mean expression fo
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br Discussion The present study showed that the
2021-09-08
Discussion The present study showed that adefovir the factors of pre-exposure and glutamate drug injections might affect the total latency time. However, the factor of sex did not affect the total latency time. The results indicate that the glutamate system and pre-exposure, but not sex, influenc
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The glucokinase protein sequence is most closely related to
2021-09-08
The glucokinase protein sequence is most closely related to the C-terminal domain of 100kD hexokinases, thus for glucokinase to evolve from a larger hexokinase ancestor it must have lost its N-terminal kinase domain. The genetic mechanism by which this occurred is currently unknown. Here we propose
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br Introduction When human red blood cells
2021-09-08
Introduction When human red blood Cinchonidine (hRBC) are suspended in depolarising Ringers, they respond by opening a non-selective voltage-dependent cation pathway, the NSVDC channel, which is permeable to mono- and divalent cations [1], [2], [3]. In patch clamp experiments on excised hRBC insi
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Gal is a amino acid residue peptide comprising amino
2021-09-08
Gal is a 29-amino Helioxanthin derivative 5-4-2 sale residue peptide, comprising 30 amino acids in humans, isolated from the porcine intestine 30 years ago (Tatemoto et al., 1983). It has been shown to be involved in the regulation of numerous processes, including neuroendocrine control of systems
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For functional metagenomics based gene screening the DNA lib
2021-09-08
For functional metagenomics-based gene screening, the DNA library construction approach is widely used . Fosmid and cosmid libraries are usually used to explore novel genes. Lee et al. reported that a halotolerant and protease-resistant α-galactosidase was identified from the gut metagenome of , a
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br Materials and Methods br Results
2021-09-08
Materials and Methods Results Discussion In the present study, we investigated the postnatal expression of the two GABA receptor subunits, GABAAα1 and GABAB1, in order to determine the differential expression and regional distribution pattern of them between right and left hippocampi in the
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In the light of the above mentioned
2021-09-08
In the light of the above-mentioned considerations, it is interesting to note that the FPR-related research with regards to bias agonism did not prosper during considerably during the last decade (possible exceptions are [[8], [9], [10], [11]]. However, with new insights in receptor chemistry and fu
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br Site of expression FASTK is expressed in various
2021-09-08
Site of expression FASTK is expressed in various parts of human body including heart, skeletal muscle, brain, placenta, lung, liver, kidney pancreas (Ota et al., 2004) and many other organs (Fig. 1). It has been reported that FASTK is highly expressed in pancreatic tumors, where it is involved in
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In the current study we report the properties of P
2021-09-08
In the current study, we report the properties of P. anserina mutants carrying mutations in a gene encoding the bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). This enzyme catalyzes two opposite reactions (Pilkis et al., 1995, Rider et al., 2004): synthesi
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The presence of FBP in
2021-09-08
The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas
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During the activation of the coagulation cascade factor
2021-09-08
During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium WP 1130 synthesis on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directly inhi
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