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We speculated modulation of redox balance
2021-12-18
We speculated modulation of redox balance in brain, by activation of GIP receptor pathway. QA is known to mediate production of ROS, lipid peroxidation by its interactions with Fe2+ and formation of QA-Fe2+ complex (Braidy et al., 2010, Rios and Santamaria, 1991, Stipek et al., 1997). QA induces NOS
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br Discussion RBCs possess a much
2021-12-18
Discussion RBCs possess a much simpler composition and structure than other eukaryotic Oseltamivir phosphate and can therefore serve as a convenient system on which to study how cell functioning relates to the molecular and supramolecular properties of its constituents. The model developed in th
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Retinal GAL receptor distribution suggests an
2021-12-17
Retinal GAL receptor distribution suggests an intrinsic neuronal control since retina lacks an autonomic innervation, and a signal modulation seems most likely here, acting via GALR1 while GALR2 and GALR3 seem to play a rather minor role in this signal transduction. While sources acting on these ret
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Tioconazole In the course of our ongoing attempts
2021-12-17
In the course of our ongoing attempts to photolabel allosteric binding sites of γ-aminobutyric Tioconazole type A (GABAA) receptors, we were met with the need for relatively large (near mg) quantities of recombinant protein. Rather than establishing a stable cell line we sought to optimise the proc
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Methods Very briefly PLA polymeric nanoparticles as well as
2021-12-17
Methods Very briefly: PLA polymeric nanoparticles as well as liposomes were synthesized and loaded with three different FGFR inhibitors. The encapsulation efficiency, average size, PDI, zeta potential, stability and release kinetics were investigated. The most promising formulations were biological
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LPCs have been previously described as potential anti
2021-12-17
LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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Sperm capacitation was negatively r
2021-12-17
Sperm capacitation was negatively (r = −0.68; p ive but not significant (r = 0.22). No significant relationship was observed between the expression levels of either CB1 receptor or FAAH and any of the sperm quality parameters studied. The scatter plot distribution of spermatozoa expression of CB1 an
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There are several limitations in our study First only
2021-12-17
There are several limitations in our study. First, only the naturally occurring resistance-associated mutations in patients coinfected with HIV/HCV FAUC-365 australia 1b were analyzed. The result was only applicable to HCV genotype 1b, but not the HCV genotype 1a patients. We did not analyze the ef
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AGK7 GCIPs are highly conserved Ca binding
2021-12-17
GCIPs are highly conserved Ca2+-binding proteins first discovered in the frog [42] and later in teleost [9]. With regard to gene structure, sequence conservation, and function, GCIPs are evolutionarily related to the GCAPs. The GCIP genes have acquired an additional intron in the N-terminal region w
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Level of CD and other blood parameters in patients
2021-12-17
Level of CD4 and other blood parameters in patients before and after intervention are presented in Table 2. The mean of the CD4+ level before treatment in the intervention and placebo groups was 161.5 ± 291.1 and 159.9 ± 337.4, respectively (P = 0.232), which increased after treatment in both groups
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br Recent insights into EAAT structure
2021-12-17
Recent insights into EAAT structure/function aspects The EAATs are secondary-active transporters coupling the movement of one Glu with the symport of three Na+ and one proton and the counter-transport of one K+ [3, 4]. The transporters are trimeric assemblies of protomers that function independen
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At the second step blind
2021-12-17
At the second step, blind docking simulation of 150 independent runs was performed with smaller grid box. Structures of open (1v4t.pdb), semi-closed (4dch.pdb) and two structures of closed configuration of GK (pdb codes are 1v4s and 3vev) were used for simulation (for detailed explanations on can se
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Recent studies are beginning to explore this
2021-12-16
Recent studies are beginning to explore this complex interplay of pathways. For example, intracellular trafficking of poly(lactic-co-glycolic acid)(PLGA) based nanoparticles was studied in detail using 30 different Rab proteins as markers for intracellular transport vesicles (involved in exocytosis,
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br Hedgehog in chronic liver disease The
2021-12-16
Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li
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Cux is a cell cycle dependent transcription repressor that
2021-12-16
Cux1 is a Lauric Acid dependent transcription repressor that is aberrantly expressed in the Pkd1 null, Pkd1CD, and cpk mouse models of PKD, as well as in human ADPKD cells (Vanden Heuvel et al., 1996; Sharma et al., 2005; Paul et al., 2011; Alcalay et al., 2008). In Pkd1 null mice and in human ADPKD
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