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On the other hand histone deacetylase inhibitors
2022-01-25
On the other hand, histone deacetylase inhibitors can accelerate inflammation resolution by promoting the externalization of AnxA1, a main ALX/FPR2 agonist, with concomitant inhibition of cytokine gene expression in mouse macrophages [30]. Thus, our present results provide an additional mechanism, i
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Methods and materials Escherichia coli JM DE cells containin
2022-01-25
Methods and materials Escherichia coli JM109(DE3) oicr containing a derivative plasmid of pUCmod that encodes E. coli FDPS (IspA) previously described by Schmidt-Dannert and co-workers [22] were grown in LB media containing 150μg/mL of ampilicin. E. coli was grown directly from stock cells stored
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We conclude that a combination
2022-01-25
We conclude that a combination of GD2-specific CAR T cell therapy with pharmacological EZH2 inhibition deserves investigation as a new therapeutic strategy in EwS and potentially other cancers with heterogeneous GD2 expression, including osteosarcoma, various soft tissue sarcomas, melanoma, lung can
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Increasing trans epithelial transport efficiency is another
2022-01-25
Increasing trans-epithelial transport efficiency is another area where different strategies are being developed for overcoming transcytosis. Enhancing the affinity for the basal membrane and weakening apical exocytosis through the optimisation of surface hydrophobicity have been demonstrated [79]. S
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br Acknowledgments I thank Takeshi Sakaba for critical readi
2022-01-25
Acknowledgments I thank Takeshi Sakaba for critical reading of the manuscript and helpful comments. This work was supported by JSPS/MEXT KAKENHI Grant Numbers 17K19466, 17H03548. Introduction The oral route of drug application is the main route in pharmacology since it is easy to handle and o
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In neurons and neuroendocrine cells the productive
2022-01-25
In neurons and neuroendocrine cells, the productive fusion pathway is thought to initiate with the Munc18-1/Syx1 complex (Ma et al., 2013, Hughson, 2013, Lai et al., 2017). The Munc13-1 MUN domain is able to catalyze opening of Syx1 (the transition from the Munc18-1/Syx1 complex to the SNARE complex
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Fig C presents the secondary structure
2022-01-25
Fig. 1(C) presents the secondary structure arrangement of the PAS-A and PAS-B domains in both HIF-2α and ARNT. The common scaffold of the PAS domains is a β sheet with numerous flanking α helixes. The PAS-A domains of both HIF-2α and ARNT have A’α, Aβ, Bβ, Cα, Dα, Eα, Fα, Gβ, Hβ, and Iβ from the N t
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A revolution in cancer immunotherapy has recently emerged
2022-01-25
A revolution in cancer immunotherapy has recently emerged with the development of novel immunomodulatory antibodies, classified as immunostimulatory agonist monoclonal hoechst stain (mAbs) or checkpoint blocking mAbs. CD40/CD40L, as an important costimulatory pathway, mediates a broad spectrum of s
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The effect of microtubule inhibitors on HBV
2022-01-25
The effect of microtubule inhibitors on HBV infection and replication were reported previously. In the study by Dr. Ai-Long Huang's group, microtubule inhibitors promoted HBV replication in Hep2.2.15 and HepG2-HBV1.1, in which HBV DNA is integrated into the chromosomal DNA (Xu et al., 2015). Integra
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Substrate affinity and specificity can
2022-01-25
Substrate affinity and specificity can be enhanced by docking interactions, in which regions distal to the site of egfr pathway bind to grooves, pockets, or surfaces outside of the kinase catalytic cleft 1, 2, 5, 6. Like catalytic site interactions, docking interactions can involve recognition of s
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Hordenine Much of the understanding of this system has
2022-01-25
Much of the understanding of this system has come from several studies focussed on CB1. A significant amount of research has demonstrated that activation of the CB1 receptor by cannabinoid ligands stimulates food intake [10], reduces gastrointestinal motility [11], and increases lipogenesis [12] an
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The intracellular signaling that mediates the adipogenesis i
2022-01-25
The intracellular signaling that mediates the adipogenesis induced by GPR120 still remains largely unknown. In the present study we showed that TUG-891 induced the activation of [Ca2+]i and ERK1/2 signaling in 3T3-L1 cells. Moreover, incubation of TUG-891 combined with BAPTA-AM or U0126 abolished TU
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PF-431396 In recent large clinical studies AIM HIGH and HPS
2022-01-25
In recent large clinical studies, AIM-HIGH and HPS2-THRIVE, the additional treatment of nicotinic PF-431396 to statin-based LDL-C lowering therapy did not decrease the major vascular events on the patients who had atherosclerotic vascular diseases [43,44]. In the AIM-HIGH study, the secondary analy
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br Acknowledgement The author expresses her
2022-01-24
Acknowledgement The author expresses her sincere appreciation to Brian P. Kenealy, Ph.D. for his contributions to the series of studies described in this article that were conducted during his tenure in the lab, as a graduate student first and then a postdoctoral research fellow. She also thanks
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Like other RNA viruses HCV also exhibits
2022-01-24
Like other RNA viruses HCV also exhibits a high degree of genetic diversity, creating a major challenge for the development of both HCV vaccines and pan-genotypic therapeutics (Timm and Roggendorf, 2007). The virus has a total of seven genotypes, with >50 subtypes and millions of quasispecies (Cuype
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