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GT cells were treated in two
2022-03-22
GT1-7 phorbol were treated in two ways; specifically, they were either dosed or transfected with VP, reflecting the extracellular and intracellular actions of VP, respectively. A dose of 200 pg/ml VP in culture supernatants was effective in stimulating GnRH in the supernatant and cell extracts; this
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Excessive extracellular glutamate can be removed
2022-03-22
Excessive extracellular glutamate can be removed from cytochrome p450 inhibitors interstitial fluids to the blood plasma for the maintenance of proper extracellular glutamate homeostasis in the mammalian central nervous system [[5], [6], [7]]. The glutamate concentration in the blood plasma increas
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br Acknowledgements br Introduction Benzodiazepine BZ treatm
2022-03-22
Acknowledgements Introduction Benzodiazepine (BZ) treatment is widely used for quick and efficient anxiolytic and sedative responses. However, when the use is extended to longer periods, adverse effects emerge. These include tolerance to the initial drug effect, dependence as revealed by withd
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Although encoded by a single gene GR displays considerable h
2022-03-22
Although encoded by a single gene, GR displays considerable heterogeneity through the combined effects of alternative mRNA splicing, alternative translation initiation, and complex post-translational modification. Differential expression of the various GR isoforms may contribute to tissue-specific f
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br Discussion In response to
2022-03-22
Discussion In response to an increase in glucose or DHA concentration, FBPase showed nuclear import and recruitment in a peripheral cell compartment. Interestingly, FBPase and GS were co-recruited to the periphery of the cells. This is precisely the site where glycogen is initially synthesized an
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In addition to FAK P MAPK kDa
2022-03-22
In addition to FAK, P-38 MAPK (38 kDa polypeptide) serves as cross-talk effector for signal transduction, enabling this factor to play a vital role in numerous biological processes (Cuenda and Rousseau, 2007). Pharmacologically modulation of P-38 has shown to be an effective approach in the orientat
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br Acknowledgments This work was supported by the
2022-03-22
Acknowledgments This work was supported by the National Natural Science Foundation of China (31100111), the Nature Science Research Project of Anhui Province (1508085MC43), the subject construction project from Anhui Academy of Agricultural Sciences (14A1110). We would like to acknowledge the tec
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One limitation of our study was
2022-03-22
One limitation of our study was that all control dogs had histologic evidence of mild GI inflammation according to established WSAVA guidelines (Washabau et al., 2010), despite being apparently healthy purpose-bred research dogs housed in a controlled environment with no history of vomiting, diarrhe
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Introduction Histamine Imidazolyl ethylamine is an important
2022-03-22
Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric Bufalin synthesis secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine
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Introduction Histamine H Imidazol yl ethanamine mol
2022-03-22
Introduction Histamine (2-(1H-Imidazol-4-yl)ethanamine), mol.w. 111.15 g/mol belongs to biogenic amines, which arise in foodstuffs from amino acids by action of microorganism´s or tissue enzymes. Histamine (HA) is formed from the amino LY2940680 mg L-histidine by action of enzyme histidine decarbo
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br Conclusion br Acknowledgements This study was
2022-03-22
Conclusion Acknowledgements This study was supported by the China Postdoctoral Science Foundation (No.2015M581817), the National Research Council of Science and Technology Support Program (2015BAD03B05-06), and the Priority Academic Program Development of Jiangsu Higher Education Institutions
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filipin According to literature RASs V
2022-03-21
According to literature, RASs V36M, T54S, Q80K and R155K are considered primary resistance mutations to different PIs. RASs V36M and R155K can reduce susceptibility to recently approved PIs simeprevir, paritaprevir and grazoprevir [18], [31], [32]. T54S is associated to resistance for first-wave tel
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A more quantitative view of kinase specificity
2022-03-21
A more quantitative view of kinase specificity suggests a continuum of phosphorylation rates for the various substrates of a particular kinase (Figure 4A). Such differences in ‘substrate quality’ can arise from variations in phosphorylation site or docking sequences and may explain why the timing or
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Activation of sGC induces the
2022-03-21
Activation of sGC induces the generation of cyclic guanosine monophosphate (cGMP), phosphorylation of protein kinase G (PKG) and changes in activity of effector proteins such as phosphodiesterases (PDE), ion channels and ion pumps [43]. This pathway eventually leads to dilation of Imeglimin hydrochl
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Another interesting approach is to use partial
2022-03-21
Another interesting approach is to use partial agonists as starting point to develop specific antagonists like done in earlier decades [64], [65]. Possible indications for an attenuation of the NO/sGC signalling pathway might be specific neuronal disorders: an involvement in the aetiology of migrain
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