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Swainsonine br Materials and methods br
2022-03-31
Materials and methods Results Discussion Main results obtained in this work are presented in Table 1 and can be summarized as follows: 1) AEA inhibits FcεRI receptor-induced degranulation with the participation of CB2 and GPR55 receptors by a PTX-insensitive mechanism; 2) AEA does not block
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LDN193189 Hydrochloride mg The GPR receptor is also emerging
2022-03-31
The GPR55 receptor is also emerging as an important therapeutic target. GPR55−/− mice possess no overt phenotype, but were protected in models of inflammatory and neuropathic pain (Staton et al., 2008). Staton et al. (2008) reported that no GPR55 mRNA could be detected by RT-PCR in the animals. Also
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Acknowledgments Financial support from the National Natural
2022-03-31
Acknowledgments Financial support from the National Natural Science Foundation of China (81730094, 81473262 and 81573299) is gratefully acknowledged. This project was also supported by the “111 Project” from the Ministry of Education of China, the State Administration of Foreign Expert Affairs of C
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br Introduction High dose niacin
2022-03-31
Introduction High dose niacin, or nicotinic acid, has been used as an athero-protective drug for more than 50 years (Carlson, 2005, Offermanns, 2006). When taken in pharmacological doses (>1g/day), the nicotinic lp-pla2 inhibitor form of niacin modulates plasma lipid profiles including decreasin
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caspofungin Generally replacement of the aryl group was well
2022-03-31
Generally, replacement of the aryl group was well tolerated, with tetrahydropyran () and hydroxyl () functionality providing potency equivalent to and . These substitutions had no effect on selectivity versus GlyT2 and taurine transporter (TauT)—no activity was observed at micromolar concentrations
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topotecan br Material and methods br Results br Discussion
2022-03-31
Material and methods Results Discussion Organisms have developed a variety of anti-glycation defense mechanisms. In topotecan to the aldose-reductase-pathway or 2-oxoaldehyde dehydrogenase-pathway, the glyoxalase system is the only mechanism, which is not restricted to liver [19]. This syst
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Compared to previously reported atypical N glycosites that
2022-03-31
Compared to previously reported atypical N-glycosites that were identified based on the deamidation of asparagine residues after PNGase F treatment [106], [107], these two studies further validated the identified atypical motif glycosites by directly identifying their intact glycopeptides. Since the
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Crystal structures from soluble E constructs Khan et
2022-03-31
Crystal structures from soluble E2 constructs (Khan et al., 2014; Kong et al., 2013) have revealed globular protein with no regular structure in spite of having eight disulphide bonds (Kong et al., 2013). Although 62% of the protein exists in loops or disordered structures, overall it was well-defin
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Because sleep and metabolism are intimately linked the autho
2022-03-31
Because sleep and metabolism are intimately linked, the authors next move to study whether Eaat2 also controls metabolic rate. First, we must ask how sleep and metabolism are connected at a functional level. The Cy5 NHS ester allocation hypothesis of sleep posits that organisms temporally partition
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Ion dependence of mGluRs activity has been previously report
2022-03-31
Ion dependence of mGluRs activity has been previously reported, notably to Ca2+ and Cl− (Kuang and Hampson, 2006). While mGlu1 and mGlu3 receptors were demonstrated to be sensitive to Ca2+, Cl− modulation was reported for all mGluRs, with a lesser extent for the mGlu2 receptor (DiRaddo et al., 2014;
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Cy3 carboxylic acid (non-sulfonated) ICH induced striatal le
2022-03-31
ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino Cy3 carboxylic acid (non-sulfonated) transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity
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Introduction Human pathogenic Leishmania protozoa comprise
2022-03-31
Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio
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br Do the actions of GLP R agonists on the
2022-03-30
Do the actions of GLP-1R agonists on the vascular endothelium account for GLP-1R agonist-mediated cardioprotection? The previous section highlighted the recent clinical evidence from cardiovascular outcomes studies supporting the notion that GLP-1R agonists confer cardioprotective actions in pati
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Underlying this study is the hypothesized
2022-03-30
Underlying this study is the hypothesized importance of insulin and glucose metabolism on bone. In our investigation of GIP and GIPR gene polymorphisms in relation to bone phenotypes in young and old women our findings depict a complex relationship between glucose metabolism genes and bone. In the c
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Some other neuroinflammatory neuroendocrine and
2022-03-30
Some other neuroinflammatory, neuroendocrine, and neurotrophic pathway but not the ghrelin/GHSR pathway may mediate the CUMS-induced depression- and anxiety-like behaivors. The endogeous ghrelin/GHSR pathway activated by chronic mild stress may plays a role in homeostasis. With respect to the mechan
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