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Mongolian gerbils Meriones unguiculatus a social rodent spec
2022-04-11
Mongolian gerbils (Meriones unguiculatus), a social rodent species, are widely distributed in the typical steppe, desert steppe and desert habitats of northern China, Mongolia, and Trans-Baikal region of Russia. In wild, the recorded maximum lifespan (apparent longevity) was 29.5 months for female M
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As GLO is the major detoxification system of
2022-04-11
As GLO1 is the major detoxification system of reactive dicarbonyls, it is plausible that differences in production and activity of the enzyme influences AGE production and the development and/or modulation of diabetic neuropathy. Glo1 exists as a copy number variant (CNV) in many inbred strains mice
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br Conclusion br Conflict of
2022-04-11
Conclusion Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as Introduction Over the past decade, more than a hundred new biopharmaceutical products have been approved and market
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br Introduction Cherry tomato Solanum lycopersicum L is
2022-04-11
Introduction Cherry tomato (Solanum lycopersicum L.) is a commonly consumed fruit on a worldwide scale due to its characteristic flavor and high nutrition (Wei et al., 2016, Yu et al., 2014). Tomato is low in fat and calories, and is a rich natural source of nutrition and bioactive antioxidant co
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Emergent studies have recently shown that Sherpas living
2022-04-09
Emergent studies have recently shown that Sherpas living at high altitude have adaptations that make life at high altitude more compatible. Sherpas are known to have blood Hb concentrations about the same as lowlanders and Han populations [30]. This is different from what happens to lowlanders, Han
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br Introduction As a fundamental metal
2022-04-09
Introduction As a fundamental metal-dependent hydrolytic enzyme, inorganic pyrophosphatase (PPase) exhibits a specific catalytic ability, in which one molecule of inorganic pyrophosphate (PPi) can be transformed into two orthophosphate (Pi) ions [1,2]. The process of transformation is extremely e
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br Ethics approval br Availability of data and materials br
2022-04-09
Ethics approval Availability of data and materials Consent for publication Competing interests Authors contributions Introduction Glucose supply to tissues is maintained through a complex regulatory network mostly driven by the pancreatic hormones insulin and glucagon which control
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To meet the requirement of
2022-04-09
To meet the requirement of ferroptosis-based therapy, a couple of small molecule drugs and nanomaterials were introduced to the design of ferroptosis inducers, separately. As we know, iron is a key regulator of ferroptosis. When small molecule drugs are employed to induce ferroptosis, the endogenous
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To examine the biochemical characteristics of FPPS in
2022-04-09
To examine the biochemical characteristics of FPPS in Drosophila, DmFPPS has been functionally expressed in E. coli. The protein displays properties similar to mammalian FPPS, with some notable differences, including the ability to efficiently couple the homologous substrate, homodimethylallyl dipho
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In the FARM motifs of GGPPSs hydrophobic amino acids
2022-04-09
In the FARM motifs of GGPPSs, hydrophobic SGC-CBP30 are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP synthase (GGPPS
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In cardiomyocytes mechanical stress builds up via FAs
2022-04-09
In cardiomyocytes mechanical stress builds up via FAs and the related costamere structures, and excessive stress can cause cardiac hypertrophy. Cardoso et al. (2016) report a comprehensive study that demonstrates the link between stress-induced FAK activation and a FAK-mediated initiation of a trans
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Previous studies have shown that
2022-04-09
Previous studies have shown that ox-LDL-induced hepatic sinus dysfunction is the result of multiple pathways, multi-factorial regulation, and in the present study, we reported for the first time that ox-LDL regulates the basement membrane protein VN through the integrin αvβ5 pathway under high gluco
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We have expanded these studies by doing EEG recording in
2022-04-09
We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA Tranilast or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor antagonist
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The structures of KDM A
2022-04-09
The structures of KDM4A revealed a Cys-His Zn(II) binding site that is close to the substrate binding spot, which bioinformatic analyses indicated was not present in any other histone demethylase subfamily. Therefore, an alternative method to inhibit the KDM4 family (95) would be to use compounds th
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Literature review suggests a strong
2022-04-09
Literature review suggests a strong presence of central histaminergic transmission in the Griseofulvin areas targeted by caffeine to induce its behavioral actions. Interestingly, it is reported that caffeine administration increases the histamine neuronal activation and release of histamine in the b
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