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Like tBHQ and DEM treatment of Keap MEFs with
2022-05-25
Like tBHQ and DEM, treatment of Keap1+/+ MEFs with SFN increased the abundance of Hmox1 and Nqo1 mRNA, and this was blunted by LY294002 and MK-2206 (Figure 2C). However, unlike the situation with tBHQ and DEM, treatment of Keap1−/− MEFs with SFN did not increase further the elevated basal levels of
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This study does have important
2022-05-25
This study does have important limitations to consider. The utilization of a recombinant gp120 monomer (at a single concentration of 100 ng/ml) instead of live virus particles may limit the validity of our results. Moreover, extrapolation of an in vitro cell culture model to animals or humans cannot
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br Significant efforts are currently focused on non
2022-05-25
Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) Milnacipran HCl synthesis hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-con
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A major hurdle in purifying a membrane protein is
2022-05-25
A major hurdle in purifying a membrane protein is finding a detergent that can preserve the protein, after releasing it from a given membrane, in a stable and non-aggregated state during purification steps [18,50]. The ability of various detergents used to solubilize and purify membrane proteins has
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To this end we evaluated novel
2022-05-25
To this end, we evaluated novel D22 analogs for selectivity to inhibit substrate transport in OCT2, OCT3, and PMAT heterologous cell integrin inhibitors systems, and in mouse hippocampal and striatal preparations. Chosen analogs were based upon availability of essential chemical precursors (e.g. 6-
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Introduction Adaptations in the metabolism of cancers contri
2022-05-25
Introduction Adaptations in the metabolism of cancers contribute to tumor survival and growth and present opportunities to develop novel therapeutic strategies (Kelloff et al., 2005, Som et al., 1980). In particular, glutamine metabolism plays such an important role in cancer growth that a phenomen
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LPCs have been previously described as potential anti diabet
2022-05-25
LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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Our data suggest that Slc
2022-05-25
Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc
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However ghrelin has a short
2022-05-25
However, ghrelin has a short half-life of 15–20 min, because it is a natural peptide containing 28-amino acids, its clinical usefulness as a therapeutic agent may be limited (Mosińska et al., 2017; Vestergaard et al., 2007). Hence, many efforts have been made to elucidate the smallest segment of ghr
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Studies regarding secretase nowadays aim at
2022-05-25
Studies regarding γ-secretase nowadays aim at elucidating how APP is recognized and recruited. It has been suggested based on coarse-grained molecular simulation that the recognition and recruitment of substrate can occur on an extended surface covering PS1's TM2/6/9 domains and PAL motif [15]. Tran
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However at variance with the well studied
2022-05-24
However, at variance with the well-studied R form of FBP1 which is flat, the R state of FBP2 is diametrically different, with a perpendicular orientation of the upper and lower dimers (Barciszewski et al., 2016). The cruciform-like R state of FBP2 is stabilized by a unique hydrophobic motif called ‘
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br Acknowledgments br Introduction Prenyltransferase catalyz
2022-05-24
Acknowledgments Introduction Prenyltransferase catalyzes the head-to-tail condensation between isopentenyl diphosphate (IPP, 1) and an allylic prenyl diphosphate to produce several prenyl diphosphates, which are then converted into steroids, carotenoids, prenyl side-chains of quinones, and pre
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We have expanded these studies by doing EEG recording
2022-05-24
We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA amyloid beta protein or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor
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br Experimental br Results br Discussion In this
2022-05-24
Experimental Results Discussion In this study, we performed molecular docking analysis and in vitro studies to determine whether genistein binds to HIF-1α in BC Epoxomicin and identify the residues involved in this interaction. We found that some functional groups (residues) mimic the bind
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br Introduction Glycolysis plays a key role in brain
2022-05-24
Introduction Glycolysis plays a key role in Enzalutamide energy metabolism [[1], [2], [3]]. It is initiated mainly by hexokinase I (HKI), the major hexokinase isoform of the brain ([3,4] and references therein). Up to 90% of brain HKI is bound to the mitochondrial outer membrane (MOM) through the
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