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Most studies on d penicillamine
2023-01-16
Most studies on d-penicillamine-induced MG were performed before the discovery that some MG patients have anti-MuSK antibodies. After the identification of the present case, we retrospectively tested the stored frozen sera of ten earlier identified d-penicillamine MG patients with anti-AChR CP-67345
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A review has recently been published to evaluate the
2023-01-16
A review has recently been published to evaluate the potential effects of food, alcohol and cytochrome p450 inhibitors juices on the pharmacokinetics and pharmacodynamics of the drugs for BPH. The authors reviewed the PubMed database during the years 1991–2015. In addition, a digital version of Sto
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br Co http www apexbt com media diy images wb
2023-01-16
Conclusions This paper is the first meta-analysis about the association between SRD5A2 V89L polymorphism and hypospadias risk. The results of this meta-analysis have revealed that V89L polymorphism definitely increases the risk of hypospadias, and the C allele is a genetic risk factor for hypospa
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The first rationally designed dual mPGES LO inhibitor
2023-01-16
The first rationally designed dual mPGES-1/5-LO inhibitor was reported in 2008 and represents a structural derivative of pirinixic LDE225 - a synthetic agonist of PPARα with lipid-lowering properties (Koeberle et al., 2008b). Further α-alkyl- and α-aryl-substituted derivatives have been synthesized
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Since innate immune responses represent the first defense ag
2023-01-16
Since innate immune responses represent the first defense against incoming infectious microorganisms, they are particularly engaged during the early stages of viral infections. Many innate defense mechanisms rely on the engagement of pattern recognition receptors (PRRs) which are conserved, germ lin
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Thymoquinone TQ is the major active compound
2023-01-16
Thymoquinone (TQ) is the major active 51 8 derived from Nigella sativa (Woo et al., 2012). Recent animal studies support the potential of TQ for the treatment of a variety of inflammatory disorders like inflammatory bowel disease (IBD), RA, and osteoarthritis (OA) (Salem, 2005, Badr et al., 2011).
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Patients with cardiovascular disorders typically have lower
2023-01-16
Patients with cardiovascular disorders typically have lower plasma apelin levels than matched healthy controls. For example, plasma apelin levels are reduced in patients with coronary artery disease (CAD), and among CAD patients with unstable angina or acute myocardial infraction there is a further
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br Materials and Methods br Results In the
2023-01-14
Materials and Methods Results In the Base Analysis (53% of patients having access to the ALK test in both Current and Alternative Scenarios), a total of 16,583 patients were tested of whom 1,252 were assumed to be ALK-positive. A more extensive use of Ventana in the Alternative Scenario determ
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HT modulates cortical and hippocampal pyramidal cell functio
2023-01-14
5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal NHS-LC-Biotin as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al.,
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Additionally regulation of GPCR heteromerization by specific
2023-01-14
Additionally, regulation of GPCR heteromerization by specific ligands may depend not only on the affinity of ligands for receptors, but also on presence of different interacting proteins co-localizing with the receptors in the specific cell, which may induce some conformational changes and contribut
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As an alternative to chronic receptor blockade we have
2023-01-14
As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify GW788388 adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilitates th
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br Results br Discussion Autophagy is considered
2023-01-13
Results Discussion Autophagy is considered as an important process in physiological and pathological ovarian function. It is related mainly to follicular atresia and CL regression (for review see [20]). However, an involvement in luteal cell survival is also proposed [21], [22]. The present st
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2-Deoxycytidine br Experimental br Acknowledgment This paper
2023-01-12
Experimental Acknowledgment This paper was financially supported by the Project Funded by China Postdoctoral Science Foundation (2017T100186), Natural Science Foundation of Liaoning Province (20170540858), General Scientific Research Projects of Department of Education of Liaoning Province (20
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br Experimental section br Introduction Microglia were disco
2023-01-10
Experimental section Introduction Microglia were discovered as a novel cell population in LOXO-101 in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal outer plexiform layer (OPL)
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Blockers will reduce perioperative myocardial
2023-01-10
β-Blockers will reduce perioperative myocardial ischemia and studies published in the 1990s suggested that their routine administration before surgery provided protection against perioperative CV complications.31., 32., 33. Based on these early studies, several national organizations endorsed the pe
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