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Despite extensive studies on the expression of T pallidum
2023-04-06
Despite extensive studies on the expression of T. pallidum-induced pro-inflammatory cytokines, very little is known about T. pallidum-mediated intracellular signaling pathway activation, that leads to cytokine expression in macrophages. A network of signaling molecules, transcription factors, epigen
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Numerous studies have reported high glutamate
2023-04-06
Numerous studies have reported high glutamate levels in the brains of patients with depression, indicating that the glutamate system plays a crucial role in depression (Sanacora et al., 2004; Kendell et al., 2005; Hashimoto et al., 2007). Furthermore, several clinically effective antidepressant drug
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The fact that the BPloopAsn regains its Btx
2023-04-06
The fact that the α1-BPloopAsn141 regains its α-Btx binding with a Kd similar to that of the wild type α1 ECD [18], suggests that the AChBP Cys-loop does not interfere with the correct conformation of the mutant ECD. Data from analogous mutants of the human neuronal α7 subunit ECD showed improved li
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The subdivision of HT receptors started in
2023-04-06
The subdivision of 5-HT receptors started in the 1950s by Gaddum and colleagues, when they realised that in the guinea pig ileum, the effects of 5-HT could be blocked in part by morphine (M), and in part by dibenzyline (D). Gaddum and Picarelli proposed two receptor classes, 5-HT M and 5-HT D (1957)
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EPSP analogs were retrieved from PubChem database
2023-04-03
EPSP analogs were retrieved from PubChem database and docking procedure yielded about eight best binding analogs (Fig. 10). The selected molecules were further assessed for their theoretical Ki values using AUTODOCK software version 4. The predicted binding efficiency of retrieved analogs was estima
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Finally intracrine androgen synthesis metabolism can be acti
2023-04-03
Finally, intracrine androgen synthesis/metabolism can be activated thus allowing ABC294640 receptor to bypass the low levels of androgens in the circulation by producing androgens themselves (Cai and Balk, 2011, Rahman et al., 2004). Moreover, changes in AR co-regulators like the overexpression of
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br Introduction Several studies have found that hypothalamic
2023-03-28
Introduction Several studies have found that hypothalamic Akt-mediated signaling pathways play critical roles in the regulation of food intake and Gardiquimod metabolism in mammals [[1], [2], [3], [4], [5], [6]]. Central injections of the inhibitor of phosphoinositide 3- kinases (PI3 K, an upstr
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br Translational Considerations Targeting the AHR Pathway Mo
2023-03-28
Translational Considerations Targeting the AHR Pathway Modulating AHR function offers exciting therapeutic potential in host immunity and inflammation. However, the emerging concept of AHR function in a cell type-specific manner, combined with differences between AHR activation in cell culture in
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In our previous study adiponectin system
2023-03-28
In our previous study, adiponectin system (genes and proteins) expression in the porcine endometrium and myometrium was observed on Days 2 to 3, 10 to 12, 14 to 16, and 17 to 19 of the estrous cycle [23]. Adiponectin receptors expression (mRNA) in the porcine endometrium was described by Lord et al.
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br Actin cytoskeleton in protrusion Pushing
2023-03-28
Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing HS-173 filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lamellip
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The presence of different LO
2023-03-28
The presence of different 5-LO splice variants was first demonstrated in human SB-3CT receptor tumour cells and in dimethyl sulfoxide-differentiated HL-60 cells [40] and a correlation between the 5-LO splicing pattern and the malignancy of the brain tumours was found. Later, other splice variants w
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br Experimental section br Competing interests br Author
2023-03-27
Experimental section Competing interests Author's contributions Acknowledgement This research is partially supported by a seed fund for the Center for Drug Discovery and Translational Research (LS) and a research grant by Fujifilm (VPS and LS). The Sponsors played no roles in study desig
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br Results br Discussion Both ATM
2023-03-27
Results Discussion Both ATM and ATR are key regulators of the cellular response to DSBs, yet how exactly they function in concert is not well understood. Recent studies revealed that ATM is required for the resection of DSBs (Jazayeri et al., 2006, Myers and Cortez, 2006), a process necessary
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br Introduction Throughout early prophase I meiotic cells in
2023-03-27
Introduction Throughout early prophase I, meiotic cells intentionally generate DSBs as part of a stringently controlled process to initiate homologous recombination (HR). HR is a critical DSB repair pathway that ultimately permits the exchange of genetic information between homologous chromosomes
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br In vivo visualization of aromatase with
2023-03-27
In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high Evodiamine photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the living body (
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